Fogorvosi szemle, 2006 (99. évfolyam, 1-6. szám)

2006-12-01 / 6. szám

FOGORVOSI SZEMLE ■ 99. évf. 6. sz. 2006. 243 A magyar fogorvosok egyesülete XVII. Árkövy Vándorgyűlésén - Debrecen, 2006. augusztus 31-szeptember 2. - elhangzott előadások absztraktjai FULL CERAMIC SYSTEMS IN AESTHETIC DENTISTRY MARK, A.1, BODROGI, A.2 1 Department of Dentistry and Oral Surgery, University of Szeged; Parlament Dental, Budapest, Hungary Introduction: Today aesthetics is getting more and more important beside function. Patients often have concrete expectations and claims. Shaping this view, media and the Internet plays an important role. We should decide in which cases should and may we sat­isfy these expectations, and when does ethics require to talk patients out of the wished intervention? What kinds of opportunities offer themselves internationally and which of these are available in our country as well. Materials and methods: The lecture reviews the used and available purely ceramic-based systems, summa­rizing the international evidence in indications and field of application. The authors shortly introduce the way to the perfect oral aesthetic and its latest trends. The correct shoulder preparation methods meeting the re­quirements of a ceramic restoration combined with pa­tients’ periodontal health can assure a very good long­term prognosis. Results: Reviewing some cases, the authors demon­strate the use of the above-mentioned materials and methods in the everyday practice. Conclusions: Although some of the full-ceramic sys­tems have been available on the market for years, having the right experience and applying them on the right way may offer today for us a solution, which is competitive in durability with the metal-ceramic den­tures and in aesthetic respect with the composite resins. THE EFFECT OF THE SYSTEMIC INFLAMMATION ON THE SECRETION OF THE PAROTIS BARTHA, A.1,2, TARJÁN, I.1, VARGA, G.2, ZELLES, T.2, LÁSZLÓ, F.3 department of Pediatrics and Orthodontics, Faculty of Dentistry, Semmelweis University, Budapest, Hungary; department of Oral Biology, Semmelweis University, Budapest, Hungary; 3Juhász Gyula Teachers Training College, University of Szeged, Hungary Introduction: Inflammatory diseases like sialadenitis and Sjogren’s syndrome or irradiation involve partial or total absence of salivary secretion. As nitric oxide (NO) plays a crucial role in the regulation of the saliva­ry secretion, it can be useful to understand what hap­pens in salivary glands (parotis) in animals in systemic inflammation, and what is the role of NO in it. Bacte­rial endotoxins (lipopolysaccharides, LPS) can be well used to model systemic inflammation. Amylase, as other salivary protein (like mucin), has an antibacterial nature. Incubation of mucus-secreting ac­inar cells with bacterial endotoxin reduces mucin se­cretion and leads to apoptosis, processes considered to be mediated by the expression of the inducible nitric oxide synthase (iNOS). However, the effect of the LPS on the amylase secreting acinar cells is not known. Aims of the study: The authors’ aim was to investi­gate the possible role of NO in inflammation caused by endotoxin in parotis, in vivo. Methods: Male Wistar rats got 3 mg/kg Escherichia coli LPS as a bolus i.v. injection and glands were re­moved 5 hours later [1], For days prior to the study L-NAME (NG-nitro-L-arginine methyl esther, non-se­­lective NOS-inhibitor) was adimistered (0.1 mg/ml in drinking water, yielding 25 mg/kg/day) for a group of animals. In the whole parotid tissue, the NOS enzyme activity was measured by the citrulline assay. Acini were isolated from the parotid for in vitro studies and were incubated with acetyl-choline (Ach) for 30 minutes. The amylase content of samples was determined by us­ing the method of Bernfeld et al. The NOS expression of the control and LPS-treated acinar cells was assessed by Western blot and immunohistochemistry. Results: Administration of LPS in vivo resulted the in­crease of the iNOS activity in the whole parotid tissue. In addition, the Western blot analysis and the immuno­histochemistry demonstrated iNOS protein expression in isolated acinar cells, after LPS injection. In our in vitro studies, administration of LPS in vivo reduced both bas­al amylase secretion and that provoked by the Ach­­induced amylase secretion in isolated acinar cells. Treatment with L-NAME in vivo did not significantly affect either the subsequent basal or Ach-stimulated amylase secretion in acinar cells with or without LPS challenge. Conclusion: NO does not have a direct effect on the amylase secretion of parotid acinar cells, neither in physiological, nor in pathological conditions. Adminis­tration of LPS reduces the amylase secretion of cells

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