Acta Paediatrica 23. (1982)
2. szám - D. Molnár-M. Kardos-G. Soltész-S. Baranyai: Intravenous glucose tolerance test in childhood obesity
D Molnár et al : Obesity 129 erance was found in 23% of obese children. Insulin response to i.v. glucose load Basal and reactive hyperinsulinaemia could be demonstrated in the obese patients (Fig. 2). All insulin levels determined during IVGTT were significantly higher in overweight children. The degree of hyperinsulinaemia and the course of the insulin curve were similar in the different obese subgroups (HT, NHT, HI, NHI) except in the obese children with IGT. Strikingly higher insulin levels were observed in the late phase (60 and 100 min.) of the IVGTT in children with IGT compared to those with NGT (Fig. 3). Lactate, pyruvate, F F A, glycerol, cholesterol and triglyceride levels during glucose tolerance test Basal levels of these metabolites were similar in obese children and the controls (Fig. 4). 0 10 20 40 60 80 100 120 min. Fig. 1. Mean + SE blood glucose of 12 control and 33 obese children during i.v. glucose tolerance test Fig. 2. Mean + SE plasma insulin of 12 control and 33 obese children during i.v. glucose tolerance test 1* Ada Paediatriea Academiae Snentiarum H ungaricae 23, 1982