Acta Medica 45. (1988)
1988 / 1. szám - HAEMATOLOGY - P. Szénási-L. Tóth-L. Romics-L. Kammerer: Sex- and age-dependence of platelet aggregation in diabetes mellitus
Acta Medica Hungarica, Vol. 45/1, pp. 115—125 (1988) SEX- AND AGE-DEPENDENCE OF PLATELET AGGREGATION IN DIABETES MELLITUS P. SZÉNÁSI1, L. TÓTH2, L. ROMICS1, L. KÄMMERER2 ''‘Semmelweis University Medical School, 3rd Department of Medicine, Budapest, 2 Hungary, István Hospital, 2nd Department of Medicine, Budapest, Hungary Platelet aggregate ratios (PAR) were determined, and threshold concentrations (EDTM) of epinephrine, adenosine diphosphate (ADP), and collagen were estimated by platelet aggregometry in 88 IDDM and 52 NIDDM patients without hyperlipidaemia or azotaemia, and in 106 healthy volunteers to revise the question of hyperaggregability in diabetes. EDTM-s showed a tendency for negative correlation with age, significant in female but not in male controls. Similar trends were obtained in IDDM and NIDDM females, but were not in IDDM and NIDDM males. The EDTM-s of different aggregating agents positively correlated with each other. EDcq-s were higher in men than in women in both controls and IDDM patients. Similar but minor differences were observed between women and men in NIDDM. IDDM patients had significantly lower PAR and collagen EDTM, and a tendency for epinephrine and ADP to be lower as compared io the sex- and age-matched controls. The differences of PAR were the same, while those of EDTM-s were diminished in older NIDDM patients compared to the matched controls. It is concluded, that the previously observed general hyperaggregability in diabetic patients may have partly resulted from sex- and age differences. Threshold concentrations should be compared to sex- and age-matched controls. Keywords: Diabetes — platelet aggregometry — platelet aggregate ratio — sex- and age-dependence Offprint requests should be sent to P. Szénási H—1121, Eötvös u. 12., Budapest, Hungary Abbreviations: ADP — adenosine diphosphate; EDTM — threshold concentration; IDDM — insulin-dependent diabetes mellitus; NIDDM — non-insulindependent diabetes mellitus; PAR — platelet aggregate ratio Akadémiai Kiadó, Budapest