Acta Paediatrica 27. (1986)
4. szám - I. Ilyés-T. Tóth-S. Kirilina: Thyroid hormones and thyroglobulin autoantibodies in insulin dependent diabetes mellitus
3* Acta Paediatrica Hungarica 27 (4), pp. 317 —321 (1986) Thyroid hormones and thyroglobulin autoantibodies in insulin dependent diabetes mellitus I Ilyés, T Tóth, Svetlana Kirilina Department of Paediatrics, University Medical School, Debrecen Serum T4, FT4, T3, and TSH were measured in a group of children with insulin dependent diabetes mellitus and a control group. In the insulin dependent diabetes mellitus group, serum T3 concentration was significantly lower than the control values. Serum T4, FT4 and TSH level did not differ. The difference in serum T3 concentration was significant between diabetic children with good or poor control. Thyroglobulin antibodies were investigated in diabetic children by Serono’s “hTg antibodies” kit. Thyroglobulin antibodies were present in 14.6%. TSH concentration did not differ in antibody positive and negative cases, but one child with diabetes had evidence of moderately impaired thyroid reserve. During the last few years a considerable amount of evidence has been obtained for abnormal thyroid function in insulin dependent diabetes mellitus(IDDM)[l,4,7,10,12,13]. Abnormalities in circulating thyroid hormone levels, referred to as the low T3 syndrome, have been described in uncontrolled and poorly controlled patients with IDDM. In addition, diabetes as an autoimmune endocrinopathy is frequently associated with presence of thyroid autoantibodies in serum [6, 11, 14]. We have attempted to (i) compare the serum concentration of T4, FT4, T3 and TSH in a group of children with IDDM and in healthy controls; (ii) investigate the possible relationship between thyroid hormone abnormalities and the degree of metabolic control of the diabetic state; (iii) de-termine the frequency of thyroglobulin antibodies detected in sera of IDDM patients; (iv) compare thyroid function in IDDM patients with or without thyroid antibodies. Material and Methods Thirty diabetic children and adolescents (13 boys and 17 girls) and 11 healthy controls (6 boys and 6 girls) participated in the study. Mean age i SD of diabetic patients and healthy controls were not significantly different (10.6 i 4.3 years vs. 10.8 i 2.7 years). The duration of diabetes at the time of the study was 1 to 11 years (mean ± SD = 4.3 ± 3.8). The diabetic subjects were treated by two daily injections of Monotard MC and Actrapid MC insulin. Insulin dosage was prescribed according to the glucose quantity in three mine fractions collected during 8 horn periods, and blood glucose concentration measured after breakfast with the glucose Ada Paediatrica Hungarica 21, 1986 Akadémiai Kiadó, Budapest