Magyar Nőorvosok Lapja, 2006 (69. évfolyam, 1-6. szám)
2006 / 3. szám - ULTRAHANG DIAGNOSZTIKA - Kiss József-Attila - Brassai Zoltán - Makó Katalin - Szabó Béla - Kiss Szilárd Leó: Egészséges nem terhesek, egészséges és hipertóniás terhesek endothelium funkciójának vizsgálata lézer-Doppler áramlásméréssel
[11] Roberts JM, Taylor RN, Goldfein A. Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia. Am J Hypertens 1989; 700-708. [12] Simionescu N, Simionescu M. Endothelial cell biology in health and disease. New York: Plenum Press 1998. [13] Sing P, Maibach H. Iontophoresis in drug delivery: Basic principles and applications. Crit Rev Ther Drug 1994; 11: 161. [14] Ramsay JE, Ferrell WR, Greer IA, Sattar N. Factors critical to iontophoretic assessment of vascular reactivity: Implications for clinical studies of endothelial dysfunction. J Cardiovasc Pharmacol 2002; 39: 9-17. [15] Asberg A, Holm T, Vassbotn T, Andreassen AK, Hartmann A. Nonspecific microvascular vasodilation during iontophoresis is attenuated by application of hyperosmolar saline. Microvasc Res 1999; 58:41^48. [16] Judith B, Reindert G, van Pampus MG, van DoormaalSmit AJ, Rakhorst G, Aarnoudse JG. Abnormal Endothelium-Dependent Microvascular Reactivity in Recently Preeclamptic Women. Obstetrics & Gynecology. 2005; 105: 626-632. [17] Anim-Nyame N, Gamble J, Sooranna SR, Johnson MR, Sullivan MH, Steer PJ. Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study. Clin Sei (bond) 2003; 104(4): 405^112. [18] Anim-Nyame N, Sooranna SR, Johnson MR, Gamble J, Steer PJ. Resting peripheral blood flow in normal pregnancy and in pre-eclampsia. Clin Sei (bond) 2000; 99(6): 505-510. [19] Anim-Nyame N, Sooranna SR, Johnson MR, Sullivan MH, Gamble J, Steer PJ. Impaired retrograde transmission of vasodilatory signals via the endothelium in pre-eclampsia: a cause of reduced tissue blood flow? Clin Sei (bond) 2004; 106(1): 19-25. Kiss JA, Brassai Z, Makó К, Szabó В, Kiss SzL: Investigation of endothelial function by laser-Doppler flowmetry in healthy non-pregnant, healthy pregnant and hypertensive pregnant women The vascular pathophysiology of preeclampsia, a hypertensive disorder unique to human pregnancy, has been postulated to be due to endothelial dysfunction arising from abnormal placentation, as a result of a failure of adequate trophoblastic invasion into the maternal uterine vasculature. We evaluated endothelial cell dependent dilation induced by acetylcholine and endothelial cell independent dilation induced by sodium nitropruside, as well as reactive hyparaemia presuming that these forearm capillaries examined by us by laser- Doppler flowmetry, exposed to this vasoactive substances by iontophoresis, would exhibit diminished endothelium-dependent relaxation where there is an impaired endothelial function. Our results do indeed demonstrate that in women with praeeclampsia, the examined vessels failed to dilate when treated with acetylcholine, however the case was not so with sodium nitropruside. Improved understanding of the pathophysiology of praeeclampsia is necessary to allow better clinical management of this serious disorder. Keywords: praeeclampsia, endothelial dysfunction, laser-Doppler flowmetry, iontophoresis. Levelezési cím: DR. KISS JÓZSEF-ATTILA Kövesdomb u. 14/N52/16 Marosvásárhely (Dämbu Pietros Nr. 14/N52/16) Telefon: 0745 615 362 e-mail: kissjozsefattila@yahoo.com 216 Magyar Nőorvosok Lapja 69 (3) 2006.