Acta Microbiologica 42. (1995)

1. szám - Uher, F–Kiss, K.–Rácz, J.–Mihalik, R.–Puskás, É.–Alonso, M. E.: B Cell Specific Natural IgM Autoantibodies: Multifunctional Regulators of the Humoral Immune Response (A Review)

Acta Microbiologica et Immunologies Hungaríca, 42 (I), pp. 3-17 (1995) В CELL SPECIFIC NATURAL IgM AUTOANTIBODIES: MULTIFUNCTIONAL REGULATORS OF THE HUMORAL IMMUNE RESPONSE (A REVIEW) F. Uher, Katalin Kiss, Judit Rácz, R. Mihalik, Éva Puskás and Maria Б. Alonso Department of Immunology, Loránd Eötvös University, Göd, and Department of Immunology, National Institute of Haematology, Blood Transfusion, and Immunology, Budapest, Hungary (Received March 28, 1994) (Accepted March 31, 1994) Introduction ...............................................................................................................................................3 Anti-lymphocyte reactivity of natural autoantibodies ..............................................................................4 The phenomenon.......................................................................................................................................6 Properties and characteristics of the regulatory IgM.................................................................................6 The mechanism of the regulatory IgM mediated inhibition of polyclonal В cell growth.......................7 The В cell specific autoantibody does not inhibit memory В cell responses..........................................8 Appearance and expansion of the regulatory IgM producing В cell clones during ontogeny ...............9 The regulatory В cells belong into the B1 developmental lineage ..........................................................9 Implications for immunopathology: autoimmune diseases and immunodeficiencies ...........................12 Concluding remarks and speculations ....................................................................................................14 References ...............................................................................................................................................16 Introduction Over the past two decades, it has been clearly demonstrated that a high number of autoreactive В cells are present in normal humans and mice.Two to fifty per cent of all the monoclonal immunoglobulin-secreting clones, prepared from different lymphoid organs [1-8], as well as polyclonally activated normal В lymphocytes [9, 10] secrete natural autoantibodies. In humans, В cells synthesizing autoreactive IgM and IgA antibodies predominate but IgG are also found, whereas in mice, IgM-producing В cells are almost exclusively seen [11]. Most natural autoantibodies, directly encoded by the germ line and subjected to practically no mutations [12-14], are capable of Ferenc Uher, Katalin Kiss, Judit Rácz, Maria Б. Alonso Department of Immunology, Loránd Eötvös University Jávorka S. u. 14, H-2131 Göd, Hungary Rudolf Mihalik, Éva Puskás Department of Immunology, National Institute of Haematology, Blood Transfusion, and Immunology Daróczi út 24, H-1502 Budapest, Hungary 0 1217-8950/95/$ 4.00 © 1995 Akadémiai Kiadó, Budapest MAGYAR ШЮМАМУОЗ AKADÉMIA KÖNYVTARA

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