Acta Paediatrica 23. (1982)
2. szám - D. Molnár-M. Kardos-G. Soltész-S. Baranyai: Intravenous glucose tolerance test in childhood obesity
128 D Molnár et al: Obesity Table I Anthropometric characteristics of the obese and control children measurements, the calculation of body fat and the determination of plasma insulin and metabolites were done as described previously (23). The characteristic anthropometric data of obese and control children are shown in Table I. IVGTT was carried out at 08 a.m. after an overnight fast. 0.6 g/kg glucose in 40% solution was injected into the cubital vein in approximately 2 minutes. Blood samples were drawn from the other arm just before and 10, 20, 40, 60, 90, 120 min after the glucose load. KG was calculated according to the formula In2/T % X 100, where T y2 was obtained from the semilogarithmic plot of total blood glucose by the graphical method. The formula was applied to the segment from 20 to 60 min of the disappearance curve. Fasting triglyceride values above 1.7 mmol/1 were considered hypertriglyceridaemic and glucose-induced insulin response above 956 pmol/1 (mean insulin response to i.v. glucose load in obese children) was taken as hyperinsulinaemic. KG values of 1.3 or less were taken as impaired. According to these criteria, the following obese subgroups were formed: hypertriglyceridaemic (HT), non-hypertriglyceridaemic (NHT), hyperinsulinaemic (HI), non-hyperinsulinaemic (NHI), a group with impaired glucose tolerance (IGT) and with normal glucose tolerance (NGT). The mean, standard error (SE) and correlation coefficient were calculated with standard methods. Statistical significance of the difference between the means of various groups was evaluated according to Student’s i-test. Results Glucose utilization rate (KG) in obese children The blood glucose concentration of obese children after overnight fast and the peak of glycaemia after the intravenous glucose load were not significantly different from those of the controls (Fig. 1). As a result of the more rapid decline of the blood glucose concentration in the nonobese patients, the blood glucose level was significantly higher in the obese children between 20 and 80 min, but it was similar to the controls after 100 min. The KG value was lower (1.551^0.1) in obese children than in the controls (1.77^0.18), but the difference was not significant. Impaired glucose tol- Obese Control No. Mean SE No. Mean SE Age, yr 33 10.7 0.45 12 11.5 0.74 Height, cm 33 148.4 2.63 12 146.8 3.25 Weight, kg 33 60.8 3.3 12 36.5 3.06 Ideal body weight, per cent 33 148.9 3.77 12 92.2 3.95 Sum of four skinfolds, mm 33 104.7 3.61 12 35.9 3.66 Body fat, per cent 33 40.5 0.77 12 20.8 2.15 Acta Paediatrica Acidemiae Scientiarum Hwigaricae 23, 1982